Colts outside linebacker Robert Mathis will miss his second straight game Sunday, and Indianapolis also will be without defensive Cory Redding.
Both players are inactive.
Mathis and Redding both have knee injuries and will be replaced by Jerry Hughes and Ricardo Matthews. Cornerback Darius Butler, running back Donald Brown, defensive end Fili Moala, left guard Joe Reitz and nose tackle Martin Tevaseu are Indy's other inactive players.
Cornerback Vontae Davis (ankle) will start for Indy (2-3).
Injured receiver Mohammed Massaquoi is inactive for the Browns (1-5). Cleveland will also play without defensive backs Tashaun Gipson and Dimitri Patterson, linebacker Scott Fujita, running back Brandon Jackson, left guard James Pinkston and tight end Alex Smith.
Josh Gordon will replace Massaquoi in the lineup, and John Greco will take Pinkston's spot.
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