The Jacksonville Jaguars will play the San Francisco 49ers at London's historic Wembley Stadium on Sunday, Oct. 27, 2013, the NFL announced Thursday.
The game will kick off at 1 p.m. ET.
In August, the Jaguars committed to play one regular-season home game in the United Kingdom in 2013, 2014, 2015 and 2016, all at Wembley.
"Everyone associated with the Jacksonville Jaguars is very much looking forward to our four home games in London through 2016, and we're particularly thrilled and honored that our first opponent will be the San Francisco 49ers," said Jaguars owner Shad Khan.
San Francisco will appear in the International Series for a second time. The 49ers hosted the Denver Broncos at Wembley Stadium in 2010, earning a 24-16 victory before a crowd of 83,941.
"The 49ers are excited and privileged to once again serve as ambassadors for the NFL and the game of football internationally," said 49ers chief executive officer Jed York. "Our 2010 experience in London was tremendous. The atmosphere at Wembley Stadium on game day was electric. The ability for us to share 49ers football with our faithful fans internationally is a treat for everyone in our organization."
This year's International Series game features the St. Louis Rams hosting the New England Patriots at Wembley Stadium on Sunday, Oct. 28.