Steelers safety Troy Polamalu aggravated a right calf injury on Sunday that caused him to miss the previous two games.
Polamalu hopped off the field during the second quarter against the Eagles and did not return. The seven-time Pro Bowl selection had not played since the season opener but had a bye week to recover and was a full participant in practice leading up to the Week 5 contest.
The Steelers did see the season debuts of linebacker James Harrison and running back Rashard Mendenhall, but had linebacker Lamarr Woodley go down with a right hamstring injury on Sunday.
Harrison had not played this season after undergoing arthroscopic surgery on his knee, while Mendenhall is coming off a torn anterior cruciate ligament suffered in the final game of the 2011 regular season.