Newly-promoted Sampdoria marked its return to Serie A with a stunning 1-0 win over AC Milan on Sunday at the San Siro.
Andrea Costa scored the lone goal in the 58th minute, helping Sampdoria defeat 2011-12 runner-up Milan on the opening weekend of the new season.
Minus offseason departures Zlatan Ibrahimovic and Thiago Silva, AC Milan found the woodwork twice, but failed to slip a shot past Sampdoria goalkeeper Sergio Romero.
Costa fired Sampdoria in front before the hour mark as he turned a header past Milan goalie Christian Abbiati.
Milan tried to respond through Mario Yepes, but Romero pushed his shot off the post, Kevin-Prince Boateng hit the frame later in the half and Mathieu Flamini had a late chance cleared off the line.
Sampdoria finished sixth in Serie B last season, but won its playoff to secure promotion. Sampdoria could not have asked for a better start in Serie A, while Milan will be left to pick up the pieces after a forgetful opener.
Milan lost just twice at home last season, going 12-2-5.
Inter Milan 3, Pescara 0
Pescara, Italy - Wesley Sneijder and Diego Milito scored two minutes apart in the first half and Inter Milan cruised to a 3-0 victory over newly-promoted Pescara on Sunday at the Stadio Adriatico in Serie A.
Sneijder opened the scoring in the 16th minute and Milito followed in the 19th as Inter opened the new season with a convincing road win. Unlike Milan rivals AC Milan, which dropped its opener to promoted Sampdoria at home.
Philippe Coutinho added a third goal for Inter 10 minutes from time.
Napoli 3, Palermo 0
Palermo, Italy - Marek Hamsik scored in first-half stoppage time and Christian Maggio and Edinson Cavani added goals in the final 12 minutes of normal time, as Napoli opened with a 3-0 win over Palermo at the Renzo Barbera in Serie A.
Napoli and Palermo were headed to halftime scoreless when Maggio found Hamsik, who converted to the top-right corner in the closing seconds of the opening 45 minutes.
Hamsik returned the favor in the 79th, putting Maggio through for a finish to the lower left. Cavani ended the scoring when he converted a pass from Eduardo Vargas to the bottom left in the 88th.
Siena 0. Torino 0
Siena, Italy - Newly-promoted Torino earned a point in its return to Serie A on Sunday with a 0-0 draw against Siena at the Stadio Comunale.
Gaetano D'Agostino struck the woodwork for Siena, which did not have a shot on goal. Torino managed just one shot on goal.
Siena remained buried at the foot on the table with minus-five points, after it was hit with a six-point deduction prior to the season for match-fixing.
Roma 2, Catania 2
Rome, Italy - Nicolas Lopez scored one minute into stoppage time as Roma tied Catania, 2-2, on Sunday at the Stadio Olimpico to open the Serie A season.
Giovanni Marchese and Alejandro Gomez scored to give Catania a pair of leads, but Pablo Daniel Osvaldo erased the first deficit in the 58th and Lopez scored late as Roma earned a point at home.
Genoa 2, Cagliari 0
Genoa, Italy - Alexander Merkel and Ciro Immobile scored in the second half as Genoa opened the Serie A season with 2-0 win over Cagliari at the Stadio Luigi on Sunday.
Cristobal Jorquera missed a penalty in the first half for Genoa, but Merkel picked up his teammate six minutes after halftime and Immobile secured the win in the 85th.
Chievo 2, Bologna 0
Verona, Italy - Sergio Pellissier and Rinaldo Cruzado scored in the second half and Chievo downed Bologna, 2-0, on Sunday at the Stadio M.A. Bentegodi in the teams' Serie A opener.
Pellissier opened the scoring in the 64th and Cruzado followed in the 79th. Bologna had Diego Perez sent off in the 87th, ending its hopes of a comeback.
Lazio 1, Atalanta 0
Bergamo, Italy - Hernanes scored in the 18th minute as Lazio escaped the Stadio Atleti Azzurri d'Italia with a 1-0 win over Atalanta on Sunday in the Serie A opener for both sides.