Luol Deng had 17 points and 10 rebounds as the 82, at Air Canada Centre.
Chicago, which was playing its fifth straight game without reigning MVP Derrick Rose due to a strained groin, was also aided by C.J. Watson's 15 points, John Lucas III's 13 and 12 by Ronnie Brewer.
Joakim Noah added eight points, eight rebounds and five assists in the Bulls' third straight win.
DeMar DeRozan scored a game-high 23 points, while James Johnson netted 16 with seven rebounds for the Raptors, who dropped their third consecutive contest.