By Mark Lamport-Stokes
Former world number one Wozniacki took advantage of an error-strewn display by her left-handed opponent, cruising to victory in just over an hour on the stadium court at the Indian Wells Tennis Garden.
Makarova, who reached her first grand slam quarter-final at the Australian Open in January, never once held serve before the match ended when she netted a backhand.
"I felt like I played pretty good out there," Wozniacki, of Denmark, said in a courtside interview after ending the day session with her commanding performance.
"It's always pretty tough playing in the first match, as conditions are different in the match from practice. But I am so excited to be back at Indian Wells. This is one of my favorite tournaments and I always feel at home here."
Wozniacki, who beat Frenchwoman Marion Bartoli in last year's final, will next face Swede Sofia Arvidsson, a 6-3 6-3 winner against Romanian Monica Niculescu.
U.S. Open champion Sam Stosur of Australia also cruised into the third round, needing only 49 minutes with her attacking style to hammer American wild card Irina Falconi 6-0 6-3.
Stosur will next play Russian Nadia Petrova, who beat American wild card Lauren Davis 6-3 6-2.
Former champion Ana Ivanovic of Serbia gained a measure of revenge for her early exit from last year's French Open, pounding Swede Johanna Larsson 6-1 6-2.
Ivanovic, who lost to the Swede in three sets in the opening round at Roland Garros, delivered a ruthless display with her crisp ground strokes to wrap up victory in just over an hour.
In dazzling desert sunshine, the elegant Serb broke Larsson three times in the opening set and twice in the second to reach the third round of an event she won in 2008.
"I'm definitely happy about that," a beaming Ivanovic said after ending the match with consecutive aces. "I had a little bit of that (French Open) match in my mind.
"I didn't play good at the French Open, so I knew I had a better chance this time around. I felt it was a bit of an awkward match against her but I'm still so happy to get that revenge and win."
In other matches, Francesca Schiavone of Italy swept past Ukrainian Lesia Tsurenko 6-2 6-4 and German Sabine Lisicki was upset 6-1 6-4 by Spaniard Lourdes Dominguez Lino.
Second-seeded Russian Maria Sharapova, the 2006 champion, was scheduled to play Argentina's Gisela Dulko later on Saturday.
(Editing by Julian Linden)