The Clippers head to south Texas on Friday in search of their first win in the Alamo City in over a decade.
Los Angeles has lost 17 straight in San Antonio dating back to Jan. 31, 2002.
Currently the Clippers remain in first place in the Pacific Division, percentage points ahead of the Lakers despite losing three of their last four.
The Clips, who are finishing up a six-game road trip, suffered their latest setback in New Jersey on Wednesday when Jordan Farmar's three-pointer with less than a second remaining lifted the Nets to a thrilling 101-100 win over LA.
Chris Paul stuffed the stat sheet with 22 points, 10 assists, six rebounds and five steals while Blake Griffin added a double-double with 28 points and 17 boards for Los Angeles, which is 2-3 on the trek and 10-10 overall as the visitor this season. Randy Foye nailed five treys en route to 24 points.
"For us, our defense really gets us easy shots and gets our offense going. When our defense isn't doing that we make it tough on ourselves," Griffin said.
The Spurs, meanwhile, currently lead the Southwest Division by three games over Memphis and are coming off a 118-105 win over the scuffling Knicks.
Tony Parker netted 32 points and handed out six assists in that one, and six other San Antonio players scored in double figures in the win.
Tim Duncan and Manu Ginobili both finished with 17 points, while Gary Neal had 12 for the Spurs, who improved to 2-2 on a seven-game homestand. DeJuan Blair, Kawhi Leonard and Tiago Splitter rounded out the double-digits scorers with 10 apiece.
"He (Parker) owns the team," said Ginobili. "He knows, and we know, that almost every possession goes through him."
The Clips have sputtered a bit since their last meeting with the Spurs back on Feb. 18. Coming into that contest LA had won eight of 10 and were 19-9 overall but Gary Neal buried a three-pointer to deadlock things with 5.7 seconds left in regulation and then hit a go-ahead three with 25 seconds remaining in overtime in a 103-100 San Antonio win at Staples Center.
San Antonio is an impressive 15-3 overall as the host this season.