The Twins' three standouts are each returning from injury-plagued seasons in which they missed a combined 265 games. Span had two hits while Morneau and Mauer drove in runs.
None of the hits came against David Price. The Rays ace pitched a hitless first inning, striking out Morneau and Mauer.
Carl Pavano, set to start for the Twins on opening day, gave up a two-run homer in the first to Matt Joyce. Pavano allowed three hits in two innings.