Tayler Hill scored 27 points and No. 9 Ohio State never trailed in handing Indiana its 13th straight loss, 75-54 on Thursday night, even with the Buckeyes playing without Big Ten scoring leader Samantha Prahalis.
Prahalis, averaging 21. 8 points in the conference, was battling the flu. She was on the bench at the outset but then went to the locker room.
Amber Stokes added 14 points and a career-high seven assists, with Kalpana Beach matching a career high with 13 points.
Ohio State (23-3, 10-3), which has won the last nine meetings with Indiana, never trailed while staying in a tie for the top spot in the Big Ten.
Aulani Sinclair had 23 points and Quaneisha McCurty 11 for the Hoosiers (5-21, 0-13).