Bobcats coach Paul Silas wasn't on the high seventh straight game.
Ejected during a timeout, he missed the last 2 1/2 quarters of another bleak loss.
Silas was ejected as the game got out of hand, tossed after receiving two technical fouls during a timeout in the second quarter while his team trailed by 21.
The Bobcats, who are an NBA-worst 3-17, continue to deal not only with the frustration of losing, but also with injuries to some of their best players.
Gerald Henderson returned Friday from a one-game absence because of a bruised lower back, scoring seven, but D.J. Augustin missed his third straight game with a toe injury and D.J. White sat with a left knee contusion.
Shorthanded, the Bobcats lost their fourth straight game by at least 10 points after staying within single digits in their previous three losses. They also had a six-game losing streak earlier in the season,
The Atlantic division-leading Sixers, meanwhile, avoided losing back-to-back games for the first time this season.
Coming off an overtime loss to New Jersey on Wednesday, they opened with a 14-3 run sparked by Jodie Meeks' three-pointer and never looked back. Holiday scored the last seven points of the burst, including a three to cap it.
The Sixers held Charlotte to 21.1 percent shooting in the first quarter and had a 23-10 lead at the buzzer.
They continued to pour it on, scoring a season-high 36 points in the second quarter. Silas was ejected after the Bobcats took a timeout while trailing 46-25.
Meeks hit both technical free throws, ending an 18-4 run that pushed the lead from nine points to 23 with 4:48 remaining in the first half.
The Sixers led 59-37 at the break, shooting 56.1 percent in the first half, and carried a 26-point lead into the fourth quarter. They went ahead by as many as 30.
The home team has won the last five games in this series, and 19 of the last 22...The Bobcats have lost four of five and nine of their last 11 games at Philadelphia...The Sixers signed free-agent veteran center Francisco Elson earlier Friday to provide some depth at the position with Spencer Hawes (Achilles) and Nikola Vucevic (quad) missing time because of injuries. They are 2-1 on a seven-game homestand...The Bobcats return home to play Washington on Saturday.