Rookie Kyrie Irving had 25 points, seven 94.
Antawn Jamison added 20 points, seven boards and five assists for the Cavaliers, who trailed by 14 in the third quarter.
D.J. Augustin ended with 24 points and eight assists for the Bobcats, who fell to 3-11 on the season. Gerald Henderson and D.J. White donated 17 and 15 points, respectively.