He was expected to start prior to suffering the injury, but instead was undergoing an MRI exam Friday afternoon.
"It's fresh, it was early in practice and then he went in and I'm sure he'll be evaluated to see where he's at," Browns head coach Pat Shurmur said.
Hillis, who was limited in practice the last two days, has missed the last two games due to the injury. He last played in a 24-17 loss to the Oakland Raiders on October 16, and has 60 carries for 211 yards and two touchdowns this season.
"If he's not ready to go, we just move on," Shurmur said about Hillis. "I think that's the mindset at any position."
Additionally, defensive lineman Auston English (knee) and cornerback Dimitri Patterson (knee) were both ruled out for Sunday.