Joseph Randle scored four touchdowns, two on runs that capitalized on big defensive plays by Shaun Lewis, as No. 6 Oklahoma State remained unbeaten and ended Missouri's 10-game home winning streak with a 45-24 victory on Saturday.
Randle had 138 yards on 14 carries and scored on runs of 16, 59 and 12 yards. He also caught a 13-yard touchdown pass in the second quarter.
Brandon Weeden had three touchdown passes after the opening snap of the second quarter. Lewis' interception and fumble recovery helped the Cowboys (7-0, 4-0 Big 12) pull away despite injuries to both starting wide receivers.
Justin Blackmon caught a touchdown pass in the first quarter before hurting his right shoulder. Hubert Anyiam was wearing a boot on his left foot in the second half.
Henry Josey had 138 yards on 25 carries and T.J. Moe had six catches for 103 yards and a score for Missouri (3-4, 1-3), which has yet to win consecutive games.
The Tigers had a strong second quarter, scoring on an 18-yard run by Kendial Lawrence and Moe's 34-yard catch from James Franklin to cut the deficit to seven, before being undone by mistakes. Franklin threw two interceptions and lost a fumble at the Oklahoma State 4, all in the second half.
Lewis intercepted a tipped pass at the Missouri 27 and three plays later Randle scored on a 16-yard run for a two-touchdown cushion midway through the third quarter.
Missouri appeared to regain momentum when E.J. Gaines intercepted Weeden in the end zone and returned it 54 yards, also ending Weeden's string of 194 consecutive passes without a pick. Franklin's lost fumble gave the Cowboys possession at the 12, and again they needed just three plays to respond with Randle's 59-yard jaunt making it 38-17.
Weeden was 33 for 49 for 338 yards after a sizzling start. The 28-year-old senior was 19 for 25 for 214 yards in the first quarter, with all six incompletions on drops.
Michael Harrison was wide open on a 27-yard catch and Blackmon caught an 8-yarder for his 28th receiving touchdown in 19 games. On the first play of the second quarter, Oklahoma State went up 21-3 on Weeden's 13-yard TD pass to Randle.
A trick play produced Missouri's best play of the quarter, with Franklin throwing a lateral pass to Moe and then getting it back for a 31-yard gain to the 13. But the Tigers stalled, settling for a short field goal by Grant Ressel.