Kenjon Barner and De'Anthony Thomas filled in 27 victory over 18th- ranked Arizona State.
James, last year's Heisman Trophy runner-up, was sidelined with an elbow injury, while quarterback Darron Thomas suffered a knee injury early in the second half Saturday.
Still, the Ducks (5-1, 3-0 Pac-12) had enough weapons to maintain their status as the conference favorites. Barner rushed for 171 yards and one TD on 31 carries, while De'Anthony Thomas scored twice for Oregon, which has won seven straight against the Sun Devils.
Brock Osweiler threw for 291 yards with two touchdowns and two interceptions on 29-of-46 attempts for ASU (5-2, 3-1), which had won three straight to start Pac-12 play.