Ryan Tannehill threw for a touchdown and rushed 40 victory over the Texas Tech Red Raiders.
It was the 70th meeting between the teams and will be the final time they face each other as Big 12 Conference foes. The Aggies have made the decision to join the Southeastern Conference.
Tannehill completed 16-of-26 passes for 188 yards and carried the ball 10 times for 55 yards as Texas A&M (3-2, 1-1 Big 12) snapped a two-game losing streak.
Cyrus Gray rushed for 116 yards and a score, and Christine Michael added 52 yards on the ground with a touchdown for the Aggies.
Seth Doege threw for 391 yards on 44-of-66 pass attempts for Texas Tech (4-1, 1-1).
Eric Stephens racked up 102 yards and a touchdown on 22 carries for the Red Raiders, while Alex Torres caught eight balls for 111 yards and a score.