Manningham practiced for the first time since suffering a concussion in week two's Monday night game against St. Louis.
The 25-year-old fourth year pro has caught seven balls for 105 yards so far this season. Manningham's back up, Victor Cruz, had 110 yards receiving and two touchdowns on three receptions in Sunday's 29-16 win over Philadelphia.
Osi Umenyiora took the field for the first time since undergoing arthroscopic knee surgery on August 19.
Second-year player Jason Pierre-Paul has registered 4 1/2 sacks in his absence.