Epiphanny Prince led the Sky with 18 points off 67 victory over the Washington Mystics.
Sylvia Fowles added a double-double with 14 points and 12 rebounds, and Tamera Young dropped in 12 points as the Sky defeated the Mystics for the sixth straight time.
Crystal Langhorne paced the Mystics with 19 points, nine rebounds and five assists. Kelly Miller scored 13 and Matee Ajavon added 12 points in Washington's seventh straight defeat.
Chicago led by as many as 19 and never trailed in the game.