The Wildcats (22-7, 11-5 Southeastern Conference) trailed 33-30 at the half after the Tigers' Alli Smalley swished a 35-footer at the buzzer.
Kentucky used a 10-0 run in 2:58 to go up 50-43 with 10:34 to go, then, when the Tigers closed to 57-52, the Wildcats ripped off a 12-3 run ending in a Maegan Conwright three-point play and a 69-55 lead with 3:26 left.
The Wildcats put three more players in double figures: A'dia Mathies scored 13, Keyla Snowden netted 11 and Conwright added 10.
Kentucky shot 26 of 34 (76.5 percent) from the line and forced the Tigers into 29 turnovers.
Smalley led the Tigers (15-14, 8-8) with 24 points, Morgan Jennings scored 16, and Chantel Hilliard and Blanche Alverson each added 10.