Duquesne rallied from eight points down in the final 5 minutes to upset No. 13 Ohio State 71-67 on Tuesday.
Ohio State (8-3) led 65-64 before the Dukes took the lead on Orsi Szecsi's two free throws with 1:49 left. She followed with a field goal 27 seconds later before Jantel Lavender made a field goal to make it 68-67.
The Buckeyes had a chance to take the lead but Samantha Prahalis missed a contested layup and Duquesne's Kelly Britcher made a 3-pointer with 9 seconds left for the final margin.
Prahalis scored 22 points and Jantel Lavender had 21 for the Buckeyes.
Wumi Agunbiade led the Dukes (10-2) with 17 points before fouling out with 2:23 to play.
Ohio State opens defense of its sixth straight Big Ten regular season title Thursday at Michigan.