Fred Lewis' sacrifice fly capped a four-run rally in the ninth inning and lifted Toronto to a 6-5 victory over Boston on Thursday, just the Blue Jays' third win in 12 games against the Red Sox this season.
Trailing 5-2, Toronto's Jose Bautista chased John Lackey by leading off the ninth with his major league-leading 36th homer. Jonathan Papelbon (4-5) came on and blew his sixth save of the season, and his first in 25 career chances against the Blue Jays.
Vernon Wells greeted Papelbon with a double and scored when Adam Lind lined a single up the middle. Pinch-runner Dewayne Wise stole second and moved to third when Aaron Hill singled off Papelbon's left foot.
Papelbon stayed in the game and struck out Travis Snider, but Encarnacion tied it with a double down the line in left. Pinch-hitter Lyle Overbay was walked intentionally to load the bases for Lewis, who hit a fly ball to shallow center off Daniel Bard. Hill tagged up and slid home well ahead of the throw from Jacoby Ellsbury.
Kevin Gregg (1-4) pitched one inning for the win.
David Ortiz and Jed Lowrie hit solo homers for the Red Sox, who had won 10 of their previous 11 in Toronto.
Lackey came in having allowed 13 earned runs in 10 2-3 innings over two starts against the Blue Jays this year but was better in this one, allowing three runs and eight hits in eight-plus innings. He walked one and struck out four.
Lowrie and Ortiz both hit solo shots in the fifth, giving Boston eight homers in the series and 155 this season. Only Toronto (179) has hit more.
Ortiz's homer was his 25th of the season, the seventh time in his Red Sox career he's reached the plateau. Only Ted Williams (14) and Jim Rice (7) have had as many 25-homer seasons with Boston.
Lowrie's homer was his first of the season and first since a grand slam against Cleveland last Oct. 4, the final game of the 2009 regular season.
The Red Sox opened the scoring with two in the third when Victor Martinez hit a sacrifice fly and Ortiz followed with an RBI single.
Toronto cut the deficit in half in the fourth when Bautista scored on Lind's double play grounder.
Lowrie led off the fifth with a drive to center. One out later, Ortiz lined a 3-2 pitch over the wall in right.
Toronto pulled to 4-2 in the sixth on another double play, with Lewis scoring on Bautista's grounder, but the Red Sox pushed the lead back to three on Darnell McDonald's RBI triple against Scott Downs in the eighth.
Blue Jays left-hander Brad Mills allowed four runs and seven hits in 4 1-3 innings. He walked two and struck out a season-high seven.
Mills was optioned back to Triple-A Las Vegas after the game, with lefty Marc Rezepczynski coming up from Las Vegas to start Friday when the Blue Jays begin a three-game road series against the Los Angeles Angels.
NOTES: Overbay was held out of the lineup with Lind starting at first base. ... Boston SS Marco Scutaro got the day off, with Lowrie starting in his place. ... Red Sox LHP Hideki Okajima (right hamstring) threw at 120 feet on flat ground Wednesday, manager Terry Francona said.