"But when we do [approve it], I'm sure you're going to be nailed in ads, 'Well they voted on that' 30 second ads," Biden told roughly 200 members of the House Democratic Caucus gathered for their three day annual retreat.
"I promise you as [a colleague] once said to me, 'I'll come campaign for you or against you, whichever will help you the most in your district.' And so will the president because, again, we're all in this together."
The vice president also offered some trademark candor about the prospects of success.
He recalled a recent White House meeting with the president and senior aides in which they were discussing the many challenges the country faces.
"If we do everything right, if we do it with absolute certainty, there's still a 30 percent chance we're going to get it wrong," was his message at the meeting.
Biden warned that the consequences were too great for the country to allow politics to prevent action.
"The only thing we can get wrong is not reaching a consensus among ourselves ... and demonstrating to the American people that we're thinking small and politically -you [House Democrats] have not, you've thought big," he said. All but 10 House Democrats voted for the bill.
Echoing President Obama's remarks Thursday, Biden aligned this moment with other great challenges the country has faced.
"Not since World War II has a caucus gathered with so many challenges facing our country and the stakes so high," he said. "The slope is pretty steep. The opportunities are great."