Updated

Chelsea Handler got in deep doo-doo with Comcast brass over a joke about Al Roker’s unpredictable bowels that also smeared Roker’s “Today” colleague Matt Lauer, sources tell us.

Roker recently confessed to “Dateline” that he once “pooped” his pants at the White House, and news of the accident, ahem, exploded online.

Handler responded with a zinger on her E! show, “Chelsea Lately,” saying, “This isn’t the first time a ‘Today’ show cast member was in the news about this sensitive subject. For years it was common knowledge that Matt Lauer spent every morning [s - - ting] all over Ann Curry.”

But Handler’s bosses — Comcast owns NBC and E! — were apparently not as amused as her audience.

“Chelsea’s writers were warned to lay off Matt,” says a source close to the show. “They don’t want them making more fun of Matt and the Ann Curry situation right now.” Lauer’s been a public target since Curry was canned as co-host of “Today” and replaced by Savannah Guthrie.

An E! rep said the story was "absolutely false, and no such request was made.”

Click here for more on Handler and Lauer from The New York Post.