And while a few weeks on set was one thing, living the vegan/macrobiotic, hallucinogenic drug-taking, multiple sex partners and au natural lifestyle away from the lights and camera would be another.
But what would be hardest?
“It would be a toss up between the idea of free love and no doors on the bathrooms,” Aniston told FOX411’s Pop Tarts column at the film’s premiere in Los Angeles.
The former 'Friends' star said the movie was a blast to make.
“You are gonna laugh your ass off, it’s bizarre and nothing you are prepared for – hopefully you have as much fun watching it as we did making it," she said. "We laughed the whole time.”
Just be ready to see Aniston as you’ve never seen her before: going to the bathroom in the bushes, having drug trips, and stripping down.
“There’s a lot of nudity,” she said. “I partially partake in the nudity.”
But it was co-star Joe Lo Truglio who had it the worst.
“It was a little bit awkward the first day when Joe came out and he had his prosthetic bits down here,” Malin Ackerman, who plays a sex and yoga loving beauty in the movie, told us. “He’s a sweet guy and he was such a trooper. Everyday getting something glued on your crotch is not that exciting, but everyday he rocked it. We got used to seeing him naked all the time.”
One thing Ackermann too couldn’t quite wrap her head around was sharing her husband.
“I like my privacy,” she insisted. “But if that’s what floats your boat, then go for it.”
Director David Wain said he used “Wanderlust” as a means to channel his own frustrations and questions, having been a New Yorker living with his wife and sons in a cramped apartment he could barely afford.
“There’s a fantasy about living life (in a commune) like that,” he mused. “Absolutely I think we can all do with being a little (less uptight). You can shoot for the extremes like the people in this movie, or just take it in little bits and pieces.”
Hollie McKay has been a FoxNews.com staff reporter since 2007. She has reported extensively from the Middle East on the rise and fall of terrorist groups such as ISIS in Iraq. Follow her on twitter at @holliesmckay