Salim Abu-Ahmad was killed in a U.S. airstrike near Idlib, Syria on Sept. 20. He was responsible for planning, funding, and approving trans-regional al Qaeda attacks.
"There are no indications of civilian casualties," U.S. defense officials said.
The Associated Press reported Sept. 20 that a drone strike hit a vehicle traveling on a rural road in rebel-controlled northwestern Syria, killing at least one person.
The Civil Defense team, known as White Helmets, said the unidentified body was lifted from the car along the Idlib-Binnish road east of Idlib province.
U.S. Central Command said American forces had conducted a "kinetic counterterrorism strike" near Idlib province targeting a senior leader of the militant group al Qaeda.
"Initial indications are that we struck the individual we were aiming for, and there are no indications of civilian casualties as a result of the strike," said Navy Lt. Josie Lynne Lenny in a statement.
The Syrian Observatory for Human Rights said the vehicle had been carrying a militant linked to al Qaeda.
The U.S. has carried out attacks in Idlib before, targeting al Qaeda militants and the leader of the Islamic State group, Abu Bakr al-Baghdadi, who was hiding in the province after fleeing from eastern Syria.
The Associated Press contributed to this report.