Those disturbances moving east will reinforce the cold, snow and terrible travel conditions.
Winter weather advisories are in effect where several inches of snow will move through over the next few days.
Some areas could see 6 to 12, even 18 inches of snow in higher elevations in total from these multiple systems.
Heavier snow develops across the Northern Rockies beginning Wednesday.
The frigid conditions are already having impacts on travel. Parts of Iowa saw up to 9 inches of snow on Monday as a narrow band of frozen precipitation developed across the state.
A snow squall warning was issued along the Interstate 80 corridor, as the Des Moines area saw whiteout conditions.
Multiple traffic accidents were reported in the area as the National Weather Service (NWS) warned to "stay safe on the roads" due the conditions.
"The view from my office is nice- but I’m not ready for this!," Iowa State Patrol public information officer Sgt. Alex Dinkla tweeted.
Heat, fire danger continue out west
As a wintry blast sweeps across the nation's midsection, fire danger remains the story out west.
Fire danger and air quality issues will continue on Tuesday over the West, especially in California, where dry, warm conditions and gusty winds have enhanced the wildfire danger.
The weather will be great for the World Series on Tuesday night, with no major issues, temperatures in the low 80s, and mostly sunny skies.