The Prince George's County Police Department released surveillance video this week that shows the suspect brazenly firing a handgun with half of his body out of the car around 6:35 p.m.
Detectives are asking for help identifying the suspect and the vehicle, which was a dark four-door sedan with tinted windows, possibly an Infiniti.
Police do not believe that the 12-year-old girl was the target of the shooting, which happened in Capitol Heights, just outside Washington, D.C.
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Police are offering a reward of up to $2,500 in the case. Anyone with information on the shooter or the vehicle can call detectives at 301-516-5200 or Crime Solvers at 1-866-411-TIPS (8477).