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Here's what on tap for Wednesday:

Iran threatens to block inspections of its nuclear sites if confronted by the U.N. Security Council because of its atomic activities. What can be done to stop the country’s nuclear ambitions? Can a compromise be reached? We’ll ask Joe Cirincione, director of the Non-Proliferation Project for the Carnegie Endowment for International Peace.

Plus, Hillary Clinton attacks with Bush aministration in a speech, but were here "plantation" comments about Republicans out of bounds? We'll have debate with Democratic strategist Elaine Kamarck and Republican strategist Ed Rogers.

Then, we'll take a closer look at Sen. Trent Lott's political future after he announces he'll run for another term. The Republican senator from Mississippi joins us live.

And, we'll be joined by former Wonkette blogger Ana Marie Cox, who'll tell us about her new political satire novel.

This story and more only on "FOX News Live."

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Note: Topics and guests subject to change.