"I bet if you asked Brad, he'd say Zahara," the 31-year-old actress tells People magazine in an interview posted Wednesday on its Web site.
Zahara, who will be 2 next month, is the couple's middle child. They have a 5-year-old son, Maddox, and a 6-month-old daughter, Shiloh.
"Mad is very smart, but he's got a certain sense of calm. Zahara is possibly the funniest person I've ever met in my life. So dramatic and creative and loud and charming," Jolie says. "She's definitely the biggest personality in the house."
Who's the family disciplinarian?
"I am," Jolie says. "Brad can be, but if Z doesn't get the bottle from me, she'll very quickly run to Daddy."
Jolie, who stars opposite Matt Damon in the upcoming drama "The Good Shepherd," says she and Pitt are proud parents.
"Somebody said to us recently that they were happy kids, and we talked about how much that meant to us to hear," she says. "And they're good kids. God knows how we managed to do that -- but they're good kids."
The Jolie-Pitt clan, frequently photographed visiting far-flung and exotic places, is a nomadic one. Jolie has traveled throughout the world as a goodwill ambassador of the United Nations High Commissioner for Refugees. Maddox was adopted from Cambodia, Zahara was adopted from Ethiopia, and Jolie gave birth to Shiloh in Namibia, where the family had traveled for privacy.
"It's hard, and maybe one day we'll have to stay in one place," Jolie says. "I'm sure (the kids are) going to be 18 and say, 'God, I just want to stay in one place.' They'll never want to leave home!"