Ball, who gained 156 yards on 25 carries, leads the nation with 34 touchdowns, a Wisconsin and Big Ten record. Only Barry Sanders has scored more touchdowns in a season, totaling 39 at Oklahoma State in 1988.
Wilson finished with 186 yards while completing 19-of-29 passes for Wisconsin (10-2, 6-2 Big Ten), which will play Michigan State next week in the conference's first championship game.
The December 3 matchup in Indianapolis will be a rematch against the Spartans, who defeated the Badgers at home last month on a Hail Mary touchdown pass on the final play of the game.
Matt McGloin threw for 97 yards on 9-of-17 passing with one touchdown and an interception for the Nittany Lions (9-3, 6-2), who suffered their first loss in five road games this season.