Vick suffered two broken ribs against the Arizona Cardinals last Sunday, which forced him to miss practice this week.
In nine games this season, Vick has thrown for 2,193 yards, 11 touchdowns and 11 interceptions. He's also rushed for 535 yards.
Vick missed three games last season with a rib injury.
If Vick can't go, Vince Young will make his first start as an Eagle. Young has taken all the reps with the first-team offense this week.
"I feel comfortable with Vince," head coach Andy Reid said. "He's done a nice job in practice ... He's been willing to spend the time. He comes in early, leaves later and comes back after dinner."
Maclin missed practice this week with shoulder and hamstring injuries.
Offensive lineman King Dunlap (concussion) and cornerback Dominique Rodgers- Cromartie (high ankle sprain) have been ruled out.