Philadelphia, PA – Ashton Gibbs scored 16 points, Khem Birch 58 over Penn on Friday.
Nasir Robinson added 14 points and J.J. Moore scored 12 in a well-balanced attack for the Panthers (4-1), who beat their second Philadelphia Big 5 team in four days.
Friday's game, part of the Philly Hoop Group Classic, came after Pitt defeated La Salle in a close one Tuesday. The Panthers are still getting over a shocking loss to Long Beach State last week, which dropped them eight spots in the rankings.
Zack Rosen scored 22 points to lead Penn (3-3) and Tyler Bernardini had 14.
The Panthers and Quakers met for the 14th time, but first time at the Palestra since 1964. Pitt hadn't played anyone at the famed Philadelphia arena since 1986.