Ivan Aska added 12 points, seven rebounds and three assists to help the Racers (13-0, 1-0) to their best start in 75 years. The only better start was 16-0 in 1935-36.
Myles Taylor had 22 points for the Skyhawks (3-11, 0-1), who dropped to 0-3 against ranked teams this season. They lost to Louisville and Mississippi State.
Murray State is one of six Division I teams without a loss.
The Racers led the all-time series with Tennessee-Martin 39-3 and are 22-0 at home against the Skyhawks.
Murray State shot 65.2 percent from the field in taking a 36-16 halftime lead. The Skyhawks shot just 23.3 percent and were outrebounded 22-15 in the opening 20 minutes.
Isaiah Canaan, Murray State's leading scorer with a 19.3 average, entered the game needing 20 points to reach the 1,000 mark. He didn't score until 15 minutes into the game and finished with 10 but he did lead the team in assists with seven.
Less than 5 minutes into the game Canaan charged toward the basket as if he was going to lay the ball in then passed to Ed Daniel for a dunk for the first of his assists.
Both teams made four 3-point field goals but Murray State only took nine attempts while the Skyhawks took 16.
With the Racers leading by 31 points coach Steve Prohm covered his face and hung his head when Jaylen Bland attempted a layup that was leaning toward the theatrical. Less than a minute later Bland redeemed himself with consecutive layups to increase the lead to 35.