Ivan Aska added 12 points, seven rebounds and three assists to help the Racers (13-0, 1-0) to their best start in 75 years. The only better start was 16-0 in 1935-36.
Myles Taylor had 22 points for the Skyhawks (3-11, 0-1), who dropped to 0-3 against ranked teams this season. They lost to Louisville and Mississippi State.
Murray State is one of six Division I teams without a loss.
The Racers led the all-time series with Tennessee-Martin 39-3 and are 22-0 at home against the Skyhawks.
Murray State shot 65.2 percent from the field in taking a 36-16 halftime lead. The Skyhawks shot just 23.3 percent in the opening 20 minutes.