The Cornhuskers (16-3, 5-2) pulled into a three-way tie for third place in the Big Ten with Michigan and Penn State, 1 1/2 games behind league-leading Purdue.
Minnesota (11-10, 3-4), which lost for the third time in four games, posted its lowest point total of the season.
Freshman Emily Cady added 13 points and seven rebounds, and Hailie Sample had 10 points and seven rebounds for the Huskers. Hooper, who started her 50th consecutive game, had six rebounds and Lindsey Moore had eight assists.
Rachel Banham had 13 points and Leah Cotton 10 to lead the Gophers, who shot 35.5 percent and committed 19 turnovers.
Hooper started a 23-2 run that turned a close game into a blowout.