Lexington, KY – A'dia Mathies made four three-pointers and 65, on Thursday at Rupp Arena.
Bria Goss chipped in 19 points for Kentucky (9-0), which has won eight of its nine games at home this season.
Freshman Azia Bishop recorded a double-double with 12 points and 11 rebounds.
Elizabeth Williams scored 17 points and grabbed six boards for the Lady Blue Devils (6-2), who had their two-game winning streak snapped.
Tricia Liston and Williams paced Duke with eight first-half points, and Richa Jackson knocked down a jumper at the first-half buzzer to give the Lady Blue Devils a 34-31 advantage at halftime.
With the game knotted at 50 midway through the second half, Kentucky used a 12-2 run to take a 62-52 lead, capped off by a Mathies three-pointer with 4:54 left in regulation.
Chelsea Gray made a pair of free throws to make it a 64-58 game with 1:59 remaining, but Mathies' three-point play pushed the lead back to nine with 1:29 left.