Marquis Teague added 16 points and six assists for the Wildcats (28-1, 14-0 SEC), who claimed their 45th SEC crown. Terrence Jones donated 12 points and six boards.
Kentucky has won 20 in a row and extended the nation's longest home-winning streak to 51 games.
Jeffery Taylor ended with 19 points and nine rebounds for the Commodores (20-9, 9-5), who had a three-game winning streak snapped. John Jenkins and Festus Ezeli had 18 and 15 points, respectively.