Bradshaw hasn't been able to practice since suffering a cracked bone in his foot during a Week 8 game against the Dolphins. He has rushed for 440 yards and five touchdowns this season.
Brandon Jacobs will carry most of the load at running back again Sunday. He has carried the ball 78 times for 253 yards and three touchdowns in seven games this season.
Linebacker Michael Boley (hamstring) did not practice all week and is listed as doubtful on the team's injury report.
The Giants lead the NFC East with a 6-3 mark, while the Eagles sit at the bottom of the division with a 3-6 record.