Clark, who has eight receptions for 71 yards and one touchdown in two games this season, is dealing with a foot injury.
He did not practice on Wednesday, and was only able to take limited reps on Thursday.
In addition, guard Ryan Diem (ankle) was listed as questionable, as he did not practice at all this week.
Defensive end Dwight Freeney (abdominal issue) was also questionable after taking limited reps in Friday's practice. Freeney did not take the field on either Wednesday or Thursday.
Starting quarterback Kerry Collins is also listed as questionable, despite a shoulder injury that did not keep him from practice this past week.