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CC Sabathia tries to pitch the New York Yankees to a series win on Thursday when they wrap up a three-game interleague set against the Colorado Rockies at Coors Field.

Sabathia, though, enters the finale having lost two of his last three starts. Oakland defeated the big left-hander on Friday, reaching him for three runs and eight hits in six innings, while dropping him to 4-3 on the year to go along with a 3.31 ERA.

"He only gave up two runs, and he gave up one before he got an out," Yankees manager Joe Girardi said. "They fouled some pitches off. They got in some long counts, which made him throw a lot of pitches in the sixth inning, but I thought he threw OK."

Sabathia, though, stands a great chance at getting back into the win column on Thursday, as he is 9-1 with a 2.40 ERA in his last 11 starts versus the National League. He also has the second-most interleague victories in the past three-plus years behind Detroit's Justin Verlander (10).

New York continued its interleague success on Wednesday, as Brennan Boesch plated the go-ahead run with a pinch-hit, infield single in the top of the ninth inning to lift the Yankees past the Rockies, 3-2.

With the game tied 2-2, New York loaded the bases against Colorado reliever Rafael Betancourt (1-1) when Vernon Wells smacked a leadoff single before Lyle Overbay and Jayson Nix each walked around Ichiro Suzuki's bunt.

Betancourt bounced back by fanning pinch-hitter Travis Hafner before Boesch slapped a grounder to third that Nolan Arenado made a diving stop on. Arenado quickly got to his feet and fired to first, but Boesch beat the throw by a step, allowing Wells to score the deciding run.

"Sometimes my speed is kind of underestimated as a bigger guy," Boesch said of his infield hit. "I think (Arenado) thought he had more time."

Mariano Rivera worked around a two-out single in the bottom half to secure his 12th save of the season, while David Robertson (2-0) earned the victory with a scoreless eighth.

Wells collected three hits, including a two-run homer in the first, to help the Yankees snap a two-game skid and improve to a MLB-best 40-19 in interleague play since the start of the 2010 campaign.

Todd Helton hit a two-run blast to account for both runs for the Rockies, who lost for the third time in their last five games.

"We need to score some more runs," Helton admitted. "You have to tip your cap sometimes to their pitchers too."

Getting the call for Colorado on Thursday will be lefty Jeff Francis, who is 1-2 with a 7.27 ERA. Francis did not get a decision on Friday against Tampa Bay, but was not sharp, as he surrendered four runs and five hits in five innings of his team's 7-4 loss.

"I felt like if I'd made some better pitches, we could have been ahead and won this game," Francis said after the start. "I missed with a couple of pitches, and it cost me some runs."

Francis, though, beat the Yankees the only time he faced them back in 2007.

New York is 8-6 all time vs. Colorado.