San Antonio, TX – Chicago's Derrick Rose scored 29 points in 89 road win at San Antonio.
The Spurs entered Wednesday with a 13-1 record at the AT&T Center, but were outscored 21-13 in the fourth quarter to suffer the loss.
The Bulls were up 56-45 in the third when the Spurs reeled off a 15-3 run to go on top.
Duncan was essential during the push, scoring 12 points and knocking down a 19-foot jumper to make it 60-59.
San Antonio held on for a 66-65 lead after three, but Chicago went on top 71-69 early in the fourth on Ronnie Brewer's layup.
The game remained close down the stretch.
A Brewer jumper gave Chicago an 85-79 lead with three minutes to play, but Neal, who scored 15 points in the fourth, responded with a three-pointer, making it 85-82.
Rose kept the Spurs at bay, answering Neal with a contested bank shot, then knocking down an 18-footer after Duncan's bucket.
Neal scored again with a minute left, pulling the Spurs within three, 89-86, but Deng made a three-pointer on the other end to put San Antonio away.
Rose was also strong early, scoring 11 first-quarter points, though the Spurs held a 22-20 advantage after one. Buoyed by 10 points from Watson, Chicago outscored San Antonio 30-20 in the second to take a 50-42 lead into the break.
The Spurs' 13-1 home mark matched their best-ever start to a season...The Bulls improved to 15-6 on the road this season...Chicago had lost 10 of its previous 12 visits to the AT&T Center.