Bryant pulled up along the right baseline with 4.2 seconds on the clock and his jumper hit nothing but net, lifting the Lakers to a thrilling 94-92 win over the Raptors.
Following a timeout, Toronto was called for a five-second violation on the ensuing inbounds pass and Bryant made 1-of-2 from the line to make it 94-92. With 3.7 seconds remaining, DeRozan received the inbounds pass, but World Peace defended him well and his shot from the left corner at the buzzer came up well short.
Bryant finished with 27 points while Pau Gasol filled the stat sheet with 16 points, 17 rebounds and six assists for the Lakers, who concluded their six- game road trip with a 3-3 mark.
Jose Calderon netted a career-high 30 points for Toronto, which has lost four of its last five games.