Atlanta, GA – Matt Ryan threw for 316 yards and a touchdown, 17 bounce-back win.
Michael Turner rushed for 100 yards and a touchdown on 21 carries for the Falcons (6-4), who were coming off a deflating 26-23 overtime loss to the New Orleans Saints.
Roddy White had 147 receiving yards in the win, while Tony Gonzalez finished with five catches for 74 yards and a score.
Jake Locker, the eighth overall pick in this year's draft, replaced an injured Matt Hasselbeck late in the third quarter and threw a pair of touchdown passes for the Titans (5-5).
He received little help from the maligned Chris Johnson, who ran for 13 yards on 12 carries,
Hasselbeck, who suffered a sprained right elbow, led the team with 17 rushing yards.