Anderson (4-6) allowed four hits in a season-high 7 2-3 innings and left to a standing ovation. He ended a four-game losing streak that matched the longest of his career.
Then again, most everyone seems to be shutting down Seattle lately. The Mariners have scored three or fewer runs in 11 straight games.
Crisp homered in the first, Oakland's first leadoff homer of the season. It was the third leadoff home run of Crisp's career and his first since Aug. 18, 2003, against Tampa Bay.
After Crisp homered, Daric Barton followed Crisp's homer with a triple off the wall in right field that Ichiro Suzuki appeared to lose in the sun. Kurt Suzuki's RBI groundout one batter later made it 2-0.
Crisp added an RBI single in the fourth and Jack Cust singled in a run in the seventh.
Anderson struck out four and didn't walk a batter. He earned just his second win since coming off the disabled list for a second time this year on July 30 from an elbow injury. He got Casey Kotchman to ground into a double play in the second, the first of 13 straight outs by the pitcher before Ichiro's two-out single in the sixth.
Anderson was rewarded in April with a $12.5 million, four-year contract that includes club options for 2014 and 2015.
The A's have won all their meetings with the Mariners in the Coliseum this season since an opening day loss back on April 5.
Oakland won for the 15th time in its last 20 day games and improved to a majors-best 32-15 in afternoon contests.
Jason Vargas (9-9) lost his fourth straight start and was done after 4 1-3 innings, matching his shortest outing of the year. He allowed five runs on seven hits.
Gutierrez returned to the lineup after missing two games with a stomach bug and recorded an RBI for the fourth straight game. He also hit a ninth-inning double.
Notes: Anderson didn't issue a walk for the fifth time in 2010. ... Carson's fourth-inning leadoff homer snapped an 0-for-15 funk.