All eyes will be on the marquee matchup between Rafael Nadal and Nick Kyrgios at Wimbledon.
It is a rematch from 2014, when a 19-year-old Kyrgios upset then-No. 1 Nadal at the All England Club.
In other second-round action Thursday, Serena Williams and Roger Federer will play their matches at the All England Club's second biggest court.
They have won a combined 15 singles titles at Wimbledon and are accustomed to playing most of their matches on Centre Court.
This time, Federer will be on No. 1 Court against 20-year-old Jay Clarke of Britain. Williams will follow in that arena, facing 18-year-old Kaja Juvan of Slovenia.
Andy Murray will make his debut at this year's tournament, playing men's doubles with Pierre-Hugues Herbert against Marius Copil and Ugo Humbert.