2025 NFL Week 13 Predictions, Betting Odds & TV Schedule

Published November 25, 2025

There is a lot to be excited about on the Week 13 NFL schedule, including the Houston Texans taking on the Indianapolis Colts.

Here are the betting odds to dissect ahead of Week 13 in the NFL.

Check out the full NFL schedule on FOX Sports!

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Week 13 Betting Lines & Game Info

Detroit Lions vs. Green Bay Packers

Odds & Prediction

Spread: Lions (-2.5)
Moneyline: Lions -145, Packers +122
Total: 49 points
Prediction: Lions 26, Packers 21

How to Watch

Game Date: Thursday, Nov. 27
Game Time: 1 p.m. ET
TV Channel: FOX
Streaming: FOX One, Tubi and FOX Deportes
Location: Detroit, Michigan

Dallas Cowboys vs. Kansas City Chiefs

Odds & Prediction

Spread: Chiefs (-3)
Moneyline: Chiefs -180, Cowboys +149
Total: 52 points
Prediction: Chiefs 27, Cowboys 23

How to Watch

Game Date: Thursday, Nov. 27
Game Time: 4:30 p.m. ET
TV Channel: CBS
Box Score
Location: Arlington, Texas

Baltimore Ravens vs. Cincinnati Bengals

Odds & Prediction

Spread: Ravens (-7)
Moneyline: Ravens -339, Bengals +272
Total: 51.5 points
Prediction: Ravens 34, Bengals 18

How to Watch

Game Date: Thursday, Nov. 27
Game Time: 8:20 p.m. ET
TV Channel: NBC/Peacock
Box Score
Location: Baltimore, Maryland

Philadelphia Eagles vs. Chicago Bears

Odds & Prediction

Spread: Eagles (-6.5)
Moneyline: Eagles -326, Bears +261
Total: 44.5 points
Prediction: Eagles 29, Bears 19

How to Watch

Game Date: Friday, Nov. 28
Game Time: 3 p.m. ET
TV Channel: Amazon Prime Video
Box Score
Location: Philadelphia, Pennsylvania

Tampa Bay Buccaneers vs. Arizona Cardinals

Odds & Prediction

Spread: Buccaneers (-3)
Moneyline: Buccaneers -161, Cardinals +135
Total: 44.5 points
Prediction: Buccaneers 30, Cardinals 19

How to Watch

Game Date: Sunday, Nov. 30
Game Time: 1 p.m. ET
TV Channel: FOX
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
Location: Tampa, Florida

Cleveland Browns vs. San Francisco 49ers

Odds & Prediction

Spread: 49ers (-5)
Moneyline: 49ers -237, Browns +194
Total: 38 points
Prediction: 49ers 27, Browns 15

How to Watch

Game Date: Sunday, Nov. 30
Game Time: 1 p.m. ET
TV Channel: CBS
Box Score
Location: Cleveland, Ohio

Miami Dolphins vs. New Orleans Saints

Odds & Prediction

Spread: Dolphins (-6)
Moneyline: Dolphins -275, Saints +224
Total: 41.5 points
Prediction: Dolphins 24, Saints 19

How to Watch

Game Date: Sunday, Nov. 30
Game Time: 1 p.m. ET
TV Channel: FOX
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
Location: Miami Gardens, Florida

Indianapolis Colts vs. Houston Texans

Odds & Prediction

Spread: Colts (-4.5)
Moneyline: Colts -223, Texans +185
Total: 44.5 points
Prediction: Colts 24, Texans 21

How to Watch

Game Date: Sunday, Nov. 30
Game Time: 1 p.m. ET
TV Channel: CBS
Box Score
Location: Indianapolis, Indiana

Carolina Panthers vs. Los Angeles Rams

Odds & Prediction

Spread: Rams (-10.5)
Moneyline: Rams -649, Panthers +471
Total: 45 points
Prediction: Rams 31, Panthers 12

How to Watch

Game Date: Sunday, Nov. 30
Game Time: 1 p.m. ET
TV Channel: FOX
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
Location: Charlotte, North Carolina

Tennessee Titans vs. Jacksonville Jaguars

Odds & Prediction

Spread: Jaguars (-6.5)
Moneyline: Jaguars -312, Titans +253
Total: 41.5 points
Prediction: Jaguars 27, Titans 18

How to Watch

Game Date: Sunday, Nov. 30
Game Time: 1 p.m. ET
TV Channel: CBS
Box Score
Location: Nashville, Tennessee

New York Jets vs. Atlanta Falcons

Odds & Prediction

Spread: Falcons (-2.5)
Moneyline: Falcons -145, Jets +122
Total: 39.5 points
Prediction: Falcons 24, Jets 20

How to Watch

Game Date: Sunday, Nov. 30
Game Time: 1 p.m. ET
TV Channel: FOX
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
Location: East Rutherford, New Jersey

Seattle Seahawks vs. Minnesota Vikings

Odds & Prediction

Spread: Seahawks (-10.5)
Moneyline: Seahawks -637, Vikings +464
Total: 41.5 points
Prediction: Seahawks 33, Vikings 14

How to Watch

Game Date: Sunday, Nov. 30
Game Time: 4:05 p.m. ET
TV Channel: FOX
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)
Location: Seattle, Washington

Pittsburgh Steelers vs. Buffalo Bills

Odds & Prediction

Spread: Bills (-3.5)
Moneyline: Bills -201, Steelers +166
Total: 47.5 points
Prediction: Bills 26, Steelers 24

How to Watch

Game Date: Sunday, Nov. 30
Game Time: 4:25 p.m. ET
TV Channel: CBS
Box Score
Location: Pittsburgh, Pennsylvania

Los Angeles Chargers vs. Las Vegas Raiders

Odds & Prediction

Spread: Chargers (-9.5)
Moneyline: Chargers -592, Raiders +427
Total: 41 points
Prediction: Chargers 28, Raiders 14

How to Watch

Game Date: Sunday, Nov. 30
Game Time: 4:25 p.m. ET
TV Channel: CBS
Box Score
Location: Inglewood, California

Washington Commanders vs. Denver Broncos

Odds & Prediction

Spread: Broncos (-6.5)
Moneyline: Broncos -324, Commanders +259
Total: 43.5 points
Prediction: Broncos 28, Commanders 17

How to Watch

Game Date: Sunday, Nov. 30
Game Time: 8:20 p.m. ET
TV Channel: NBC/Peacock
Box Score
Location: Landover, Maryland

New England Patriots vs. New York Giants

Odds & Prediction

Spread: Patriots (-7.5)
Moneyline: Patriots -413, Giants +322
Total: 46.5 points
Prediction: Patriots 30, Giants 18

How to Watch

Game Date: Monday, Dec. 1
Game Time: 8:15 p.m. ET
TV Channel: ESPN
Box Score
Location: Foxborough, Massachusetts

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