Republican Sen. Josh Hawley of Missouri snapped his streak this week.
But overall, Hawley has voted against 12 of 13 Biden nominations.
What's one thing all four of these senators have in common?
They all may harbor national ambitions and are considered potential 2024 GOP presidential contenders.
"Senators looking to potentially run for president in 2024 need to do everything that they can to show Republican primary voters that they've fought Biden administration policies with vigor," Lauren Zelt, a longtime Republican strategist and veteran of numerous Senate campaigns, told Fox News. "Voting against Biden administration nominees helps them put together a record of opposing the president."
Doug Heye, a veteran GOP strategist and former Republican National Committee communications director, argued that nowadays in politics, "everything is about demonstrating that you can fight. Talking about your willingness to fight is seen as being as more important than any kind of ability to throw a punch or land a punch."
It's not just Republicans.
Four years ago, the top six senators who opposed nearly all of then-President Trump's nominees all eventually ran or seriously considered 2020 Democratic White House bids.
And Sens. Cory Booker of New Jersey, Kamala Harris of California (now Vice President Harris) and Jeff Merkley of Oregon voted "no" 18 times. All but Merkley eventually launched presidential campaigns.
Sanders – who ended up being the final candidate standing against Biden in last year's Democratic primaries before ending his bid and backing the eventual nominee in April – is the only member of the Senate Democratic conference (Sanders is an independent senator who caucuses with the Democrats) to so far vote "no" against one of Biden's nominees. The progressive champion opposed the confirmation of Agriculture Secretary Tom Vilsack.