She was snapped heading into a hotel while donning a casual look that included a purple tie-dye shirt and black pants and then was later spotted hopping into a car to take in the nightlife. Cuoco smiled at the camera as she got into the back seat.
The "Big Bang Theory" actress arrived in the European city to start production on Season 2 of the HBO Max dramedy. Just a few days prior, Cuoco wrapped up filming an upcoming romantic comedy with Pete Davidson in New York City.
"Despite a deep love and respect for one another, we have realized that our current paths have taken us in opposite directions," the statement begins. "We have both shared so much of our journey publicly so while we would prefer to keep this aspect of our personal life private, we wanted to be forthcoming in our truth together. There is no anger or animosity, quite the contrary."
"We have made this decision together through an immense amount of respect and consideration for one another and request that you do the same in understanding that we will not be sharing any additional details or commenting further," their statement concluded.
Cuoco and Cook celebrated three years of marriage this past June. They began dating in 2016 and became engaged the following year. They tied the knot in San Diego, Calif., on June 30, 2018.
The couple had been open about their marriage over the years and why they decided to hold off on moving in together right away. In March 2020, the actress shared they were gearing up to finally live under the same roof.
"We are built, we are so excited," Cuoco told Extra of their Los Angeles home. "We have not spent an evening in it yet. Actually Karl has been at home and I said ‘Why don’t you go and stay at the house?’ but he’s waiting for me to get there and have all the animals there."
"So when I wrap in April, that will be our first time in our new house," the actress said. At the time, Cuoco described their marriage as "unconventional."
"We have a very unconventional marriage, you know. We have different locations that we’re at a lot. We’re not together every single day," she explained.
Cuoco was previously married to tennis player Ryan Sweeting from 2013 to 2016.
Fox News' Melissa Roberto contributed to this report.