The clip, which originally surfaced on the YouTube channel "That's The Point with Brandon," begins in the midst of the confrontation. A man allegedly approached Cuomo and called him "Fredo," a likely reference to the weakling brother played by John Cazale in the iconic film.
"No, punk-ass b—es from the right call me 'Fredo.' My name is Chris Cuomo. I'm an anchor on CNN," a heated Cuomo responded. "'Fredo' was from 'The Godfather.' He was a weak brother and they use that as an Italian slur — are any of you Italian?... It's a f—king insult to your people. It's an insult to your f—kin' people. It's like the N-word for us. Is that a cool f—king thing?"
The heated argument ended without violence, but the video went viral, prompting a response from the CNN anchor.
“Appreciate all the support but - truth is I should be better than the guys baiting me. This happens all the time these days. Often in front of my family. But there is a lesson: no need to add to the ugliness; I should be better than what I oppose,” he wrote.
Since the video’s posting, some of Hollywood’s more outspoken celebrities shared their thoughts on the controversy.
Alec Baldwin was among the first to take to Twitter in support of Cuomo's reaction to the man.
"My best wishes to @ChrisCuomo," he wrote. "Nothing the Trumpers hate more than a clear-headed progressive who has no fear."
Actor Adam Baldwin sounded off on the situation as well, blaming Cuomo for overreacting.
"Wrong @ChrisCuomo, 'Fredo' simply means that you’re the dumb one. Change our minds," he wrote.
"However you feel about Chris Cuomo’s behavior today, there’s not one woman in ALL of media who could be filmed in public on an obscenity filled tirade and be supported by their network and public the way he is right now. Men get to be tough and swear, women are 'unhinged'..." she wrote.
"CNN’s Chris Cuomo: Standing with you, Chris...Any husband and father would have done the same thing to protect his family," wrote KISS rocker Gene Simmons.
"Hey “Fredo” is not a racial slur. It’s hilarious and so dumb to say it is. Also, the dude who came up to @ChrisCuomo, antagonizing him was a p—y. He deserved to be put in his f—kin place," wrote comedian Chris D'Elia.
"Mad as hell and not gonna take it anymore," wrote actor John Wesley Shipp.
"I knew it was you @ChrisCuomo, you broke my heart #fredoCuomo," Antonio Sabato Jr. mocked, referencing the film.
Chelsea Handler sassed, "If you think the Chris Cuomo situation is upsetting, then you should see what Trump’s doing to children at the border."