Cardi B is not holding back.
Melania, 50, received praise from fans after her speech, including writer DeAnna Lorraine, who shared her support on Twitter.
"America needs far more women like Melania Trump and far less like Cardi B," wrote the author, whose comment didn't go unnoticed by the 27-year-old rapper.
Her comment was in reference to her hit song "WAP," which has received criticism from listeners for its sexual explicitly. The title of the song is an acronym for "wet a-- p---y."
About 30 minutes later, Cardi B responded again, this time, sharing a throwback semi-nude photo of Melania from her days as a former fashion model.
"This pic giving me 'yea you f--kin wit some wet a-- p--y' vibes ...just saying," wrote Cardi.
The "Bodak Yellow" rapper has been very vocal about her interest in politics of late, often throwing her support behind candidates such as Bernie Sanders and Biden while offering up criticism of Republicans.
Cardi B's tweets were made during controversy over her new song, with the star recently defending it.
She went on to explain that she didn't see the song's expletives as out of line for the hip-hop industry, and explained that the song is "for adults" rather than children.