The actor, 42, used his Twitter account to sound off, claiming little has been done to help get Iowa back on its feet after a swath of destruction and power outages were a result of its 800-mile trek.
"Where is the federal relief for Iowa? 10m acres of crops have been destroyed. Houses. Communities. Wake up federal gov! What because it’s not called a tornado or hurricane you don’t need to act fast? Come On!!" tweeted the Cedar Rapids native.
"You were there campaigning. You saw with your own eyes. Do something," Kutcher tweeted to Pence.
Kutcher then tagged Trump in a couple of tweets featuring photos of the damage, one of which showed a damaged home covered in fallen trees.
Iowa Gov. Kim Reynolds said Tuesday early estimates indicate 10 million acres have been damaged in the nation’s top corn-producing state and many grain bins were destroyed. That's nearly a third of the roughly 31 million acres of land farmed in the state that sustained damage from the wind storm.
"Impressive satellite image of the crop damage from yesterday's storms showing 2 distinct damage swaths," the National Weather Service tweeted.
When the system reached Des Moines, forecasters said wind gusts were clocked at more than 100 mph. That caused devastation across farm communities.
Iowa Agriculture Secretary Mike Naig said tens of millions of bushels worth of commercial grain storage and millions of bushels of on-farm grain storage have been damaged or destroyed.
“It’s incredibly devastating to see what’s happening to crops, and to structures all across the storm path,” he told reporters.
Fox News' Travis Fedschun contributed to this report.