Officials say a bus traveling from Algeciras in southwestern Spain to Madrid has crashed into a stationary truck, killing 2 people and injuring at least 45 others.

The Interior Ministry says the accident happened in the early hours of Sunday when the bus smashed into the truck that had broken down but was not displaying any warning signs.

It says four of those injured in the crash, just south of the city of Montoro, are in serious condition.

Most of those hurt have been transferred for treatment to the Reina Sofia hospital in the nearby city of Cordoba.

Regional ministry spokeswoman Rafaela Crespin said the bus driver was among those killed.